DOSE NUMBERS // MOUSE STUDIES
MOTS-c peptide doses came from mouse studies
Lee's team found this short chain of protein pieces while studying how cells use sugar. Their work led to mouse dose tests, but it didn't set a dose for people.
What the animal dose numbers mean for you
Every MOTS-c peptide dosage number here came from animals, mostly mice. Researchers often gave the mice belly shots to study MOTS-c.
If you see "milligrams per kilogram" below, it means an amount for each kilogram the animal weighed. "Intraperitoneally" tells you the shot went into the animal's belly.
When you see protocol, read it as the written plan for a study. Compounded means a pharmacy made one drug for one patient after a doctor's prescription.
No human study has found a safe amount or schedule. It hasn't shown how long MOTS-c stays in your blood.
If this were my choice, I'd stop right there. The mouse amounts describe studies, nothing more.
What mouse amounts and prescription access mean
MOTS-c dosage in published work is expressed per kilogram of body weight, by injection, in animals. The founding metabolic studies used roughly 0.5 mg/kg/day intraperitoneally for chronic dosing (about 8 weeks) and 5 mg/kg/day for short acute studies (7 days) in mice [1]. The aged-mouse physical-capacity work used 15 mg/kg/day, or 15 mg/kg three times weekly, intraperitoneally [2]. A 2023 synthesis of MOTS-c's metabolic actions documents the broader range of study designs and durations [7].
These are animal-model figures. They cannot be converted into a human dose: the milligram-per-kilogram values, the route, and the dosing frequency were all chosen for rodent experiments, and no validated human dose-response exists [4]. This is what "how doses are expressed" means here — a description of study methods, not a protocol.
A protocol, where one exists at all, is written by a clinician rather than read off a rodent table. The prescription route for MOTS-c has opened at mypromise.com, where Promise Peptides now prescribes its compounded product. A clinician licensed in the United States examines each person's health history and may decline to prescribe. Only U.S. patients enter this process, with choices narrowed by both state and treatment. The product needs a prescription and has no FDA approval; the mouse amounts above cannot guide human care.
What we know about how long MOTS-c stays in blood
How long does MOTS-c stay in blood?
No human study has measured how long MOTS-c stays in the blood [4]. Animal studies used repeated doses, but they didn't measure how long MOTS-c stays in human blood [2][4].
Lab workers changed MOTS-c so it could enter cells more easily. No one has tested a finished medicine made from those changed versions [4].
That leaves you without a sound clock for your body. You can't use the animal timing to plan a shot or judge when an effect might start.
What kinds of shots the animal studies used
How was MOTS-c given in studies?
Most mouse studies used a shot into the belly. Other work used a shot under the skin, cells in a dish, or changed MOTS-c that could enter cells [1][2].
Researchers haven't found a proven way to give MOTS-c to people. Lab sellers may offer powder that was dried and frozen for storage, but no human drug form has been tested [4].
Where was the shot given?
Published mouse work mainly used belly shots [2]. No human trial has found a safe shot site, so the mouse method can't guide you [4].
How often did mice get MOTS-c?
There isn't a human schedule. Mice got daily shots or three shots a week, including 15 milligrams for each kilogram of mouse weight each day, or 15 milligrams for each kilogram three times weekly [2].
Those are mouse amounts, not directions for you [4]. A doctor can't turn them into a human plan without tests in people.
Can daily shots guide your care?
Some mouse studies did use a daily shot [1][2]. That doesn't give us safe timing or a safe length of use for people [4].
How long did the animal tests last?
Animal tests ran from about one week to several weeks [1][2]. Each test had its own length, which can't tell you how long a person might use MOTS-c [4].
Why a mouse dose can't set your dose
There's no safe way to turn a mouse amount into one for your body. Human studies haven't measured how much MOTS-c reaches your blood, how long it stays, or whether it helps or harms you [4].
A math formula can't replace those missing tests. Lab products may also vary in strength or contents because they aren't checked like drugs approved for your care [4].
For the law, read the federal rules for pharmacies that mix drugs for one patient. Those rules matter before anyone treats a lab amount like medicine for you.
